Background

Elderly population has been progressively rising in the world, thus the demand for anti-aging heath products to assure longevity as well as to ameliorate age-related complications is also on the rise. Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining attentions of the consumers and the scientific community.

Aim of review

This article intends to provide an overview on the current knowledge on promises and safety concerns of NMN as an anti-aging health product.

Key scientific concepts of review

Nicotinamide adenine dinucleotide (NAD⁺) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD⁺, can slow down this process by elevating NAD⁺ levels in the body. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.

中文翻译：

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烟酰胺单核苷酸 (NMN) 作为抗衰老保健品——承诺和安全问题

背景

全球老年人口不断增加，因此对抗衰老保健产品的需求以确保长寿以及改善与年龄相关的并发症的需求也在增加。在众多抗衰老保健品中，烟酰胺单核苷酸（NMN）一直受到消费者和科学界的关注。

审查目的

本文旨在概述有关 NMN 作为抗衰老保健产品的承诺和安全问题的当前知识。

审查的关键科学概念

体内的烟酰胺腺嘌呤二核苷酸 (NAD ⁺ ) 水平会随着衰老而耗尽，并且与线粒体能量产生的下调、氧化应激、DNA 损伤、认知障碍和炎症状况有关。然而，NMN 作为 NAD ⁺的前体，可以通过提高体内NAD ⁺水平来减缓这一过程。体内的一些研究表明，补充 NMN 对各种年龄引起的并发症的治疗效果是肯定的。已经进行了一项临床前研究和一项临床研究，以调查 NMN 给药的安全问题，同时正在进行更多的人体临床试验。由于市场上大量涌入基于 NMN 的抗衰老产品，因此迫切需要进行适当的临床研究，以确定 NMN 补充剂的有效性和安全性。