Mitophagy is a specific autophagic phenomenon in which damaged or redundant mitochondria are selectively cleared by autophagic lysosomes. A decrease in mitophagy can accelerate the aging process. Mitophagy is related to health and longevity and is the key to protecting stem cells from metabolic stress damage. Mitophagy decreases the metabolic level of stem cells by clearing active mitochondria, so mitophagy is becoming increasingly necessary to maintain the regenerative capacity of old stem cells. Stem cell senescence is the core problem of tissue aging, and tissue aging occurs not only in stem cells but also in transport amplifying cell chambers and the stem cell environment. The loss of the autophagic ability of stem cells can cause the accumulation of mitochondria and the activation of the metabolic state as well as damage the self-renewal ability and regeneration potential of stem cells. However, the claim remains controversial. Mitophagy is an important survival strategy against nutrient deficiency and starvation, and mitochondrial function and integrity may affect the viability, proliferation and differentiation potential, and longevity of normal stem cells. Mitophagy can affect the health and longevity of the human body, so the number of studies in this field has increased, but the mechanism by which mitophagy participates in stem cell development is still not fully understood. This review describes the potential significance of mitophagy in stem cell developmental processes, such as self-renewal, differentiation and aging. Through this work, we discovered the role and mechanism of mitophagy in different types of stem cells, identified novel targets for killing cancer stem cells and curing cancer, and provided new insights for future research in this field.

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线粒体自噬和干细胞的新见解

线粒体自噬是一种特殊的自噬​​现象，其中受损或多余的线粒体被自噬溶酶体选择性清除。线粒体自噬的减少会加速衰老过程。线粒体自噬与健康和长寿有关，是保护干细胞免受代谢应激损伤的关键。线粒体自噬通过清除活跃的线粒体来降低干细胞的代谢水平，因此线粒体自噬对于维持旧干细胞的再生能力变得越来越必要。干细胞衰老是组织衰老的核心问题，组织衰老不仅发生在干细胞中，还发生在运输放大细胞室和干细胞环境中。干细胞自噬能力的丧失会导致线粒体的积累和代谢状态的激活，并损害干细胞的自我更新能力和再生潜力。然而，这一说法仍然存在争议。线粒体自噬是对抗营养缺乏和饥饿的重要生存策略，线粒体功能和完整性可能会影响正常干细胞的活力、增殖和分化潜能以及寿命。线粒体自噬会影响人体的健康和长寿，因此该领域的研究数量有所增加，但线粒体自噬参与干细胞发育的机制仍不完全清楚。这篇综述描述了线粒体自噬在干细胞发育过程中的潜在意义，例如自我更新、分化和老化。通过这项工作，我们发现了线粒体自噬在不同类型干细胞中的作用和机制，确定了杀死癌症干细胞和治愈癌症的新靶点，并为该领域的未来研究提供了新的见解。