Semi-batch operated reaction processes are necessary for some competitive reaction systems to achieve a desirable process selectivity and productivity of fine chemical products. Herein the structural and operating parameters of the teethed high shear mixers were adjusted to study the micromixing performance in the semi-batch operated system, using the Villermaux/Dushman reaction system. The results indicate that the rising of the rotor speed and the number of rotor teeth, the decrease of the width of the shear gap and the radial distance between the feed position and the inner wall of stator can enhance the micromixing level and lead to the decrease of the segregation index. Additionally, computational fluid dynamics calculations were carried out to disclose the evolution of the flow pattern and turbulent energy dissipation rate of the semi-batch operated high shear mixer. Furthermore, the correlation was established with a mean relative error of 8.05% and R² of 0.955 to fit the segregation index and the parameters studied in this work, which can provide valuable guidance on the design and optimization of the semi-batch operated high shear mixers in practical applications.

一些竞争性反应系统需要半间歇操作的反应过程来实现精细化工产品的理想过程选择性和生产率。在此，调整齿形高剪切混合器的结构和操作参数以研究半间歇操作系统中的微混合性能，使用 Villermaux/Dushman 反应系统。结果表明，转子转速和转子齿数的增加、剪切间隙宽度的减小以及进料位置与定子内壁的径向距离的减小都可以提高微观混合水平并导致其降低。隔离指数。此外，进行了计算流体动力学计算，以揭示半间歇操作的高剪切混合器的流动模式和湍流能量耗散率的演变。此外，建立相关性的平均相对误差为 8.05%，并且R ²为0.955，以拟合偏析指数和本工作中研究的参数，可为实际应用中半间歇操作的高剪切混合机的设计和优化提供有价值的指导。