Vonoprazan-associated gastric mucosal redness is rare, and its endoscopic and pathological features remain poorly described. We report 4 cases of vonoprazan-associated gastric mucosal redness, that is, 2 cases each in non-Helicobacter pylori-infected and -eradicated stomach. In all cases, esophagogastroduodenoscopy demonstrated spotty and linear redness newly appearing in the greater curvature of the gastric body after initiation of vonoprazan but disappearing after its discontinuation. A tissue biopsy taken from the gastric mucosa with redness revealed various pathological findings and included inflammatory cell infiltration, parietal cell protrusions, oxyntic gland dilatations, congestion, focal hemorrhage with congestion beneath the basement membrane, and vacuolar degeneration of parietal cells. To our knowledge, this is the second report describing the endoscopic and pathological features of vonoprazan-associated gastric mucosal redness.
Case Rep Gastroenterol 2021;15:751–758

中文翻译：

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非幽门螺杆菌感染和幽门螺杆菌根除的胃中沃诺拉赞相关的胃粘膜发红

Vonoprazan 相关的胃黏膜发红很少见，其内镜和病理特征仍不清楚。我们报告了 4 例与沃诺拉赞相关的胃粘膜发红，即非幽门螺杆菌感染各 2 例- 感染和 - 根除胃。在所有病例中，食管胃十二指肠镜检查显示在开始使用沃诺拉赞后胃体大弯处新出现点状和线状发红，但在停用后消失。胃黏膜发红组织活检显示各种病理结果，包括炎性细胞浸润、壁细胞突出、泌酸腺扩张、充血、基底膜下充血的局灶性出血和壁细胞空泡变性。据我们所知，这是第二份描述沃诺拉赞相关胃粘膜发红的内镜和病理特征的报告。
Case Rep Gastroenterol 2021；15:751–758