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Sequence Ontology terminology for gene regulation
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ( IF 4.7 ) Pub Date : 2021-08-11 , DOI: 10.1016/j.bbagrm.2021.194745
David W Sant 1 , Michael Sinclair 2 , Christopher J Mungall 3 , Stefan Schulz 4 , Daniel Zerbino 5 , Ruth C Lovering 6 , Colin Logie 7 , Karen Eilbeck 2
Affiliation  

The Sequence Ontology (SO) is a structured, controlled vocabulary that provides terms and definitions for genomic annotation. The Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) initiative has gathered input from many groups of researchers, including the SO, the Gene Ontology (GO), and gene regulation experts, with the goal of curating information about how gene expression is regulated at the molecular level. Here we discuss recent updates to the SO reflecting current knowledge. We have developed more accurate human-readable terms (also known as classes), including new definitions, and relationships related to the expression of genes. New findings continue to give us insight into the biology of gene regulation, including the order of events, and participants in those events. These updates to the SO support logical reasoning with the current understanding of gene expression regulation at the molecular level.



中文翻译:

基因调控的序列本体术语

序列本体 (SO) 是一种结构化、受控的词汇表,为基因组注释提供术语和定义。知识共享的基因调控整体努力 (GREEKC) 计划收集了许多研究人员团体的意见,包括 SO、基因本体论 (GO) 和基因调控专家,其目标是整理有关如何调控基因表达的信息在分子水平。在这里,我们讨论反映当前知识的 SO 的最新更新。我们开发了更准确的人类可读术语(也称为类),包括新的定义以及与基因表达相关的关系。新发现继续让我们深入了解基因调控的生物学,包括事件的顺序和这些事件的参与者。分子水平的基因表达调控。

更新日期:2021-08-30
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