Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China.,Archives of Virology

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Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China.
Archives of Virology ( IF 2.7 ) Pub Date : 2021-08-09 , DOI: 10.1007/s00705-021-05198-5
Yun Lan ₁ , Linghua Li ₁ , Weiping Cai ₁ , Junbin Li ₁ , Xizi Deng ₁ , Feng Li ₁ , Chunliang Lei ₁ , Fengyu Hu ₁ , Xiaoping Tang ₁

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Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.

更新日期：2021-08-09

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