Several ocular drug delivery (ODD) systems, like hydrogels, microparticles, nano-emulsions, micro-emulsions, and liposomes have been researched, which can govern the drug release and sustain therapeutic levels for a delayed period in the eye. While new drugs targeting methods to the eye are possible by various nanoparticles. Presently in the market, there are fewer choices and need for novel nano-ocular delivery systems as well as therapies for prolonged delivery to the anterior and posterior eye segments. The primary objective of this article is to summarize current discoveries and proven activities of different nano- and microsystems in ODD. This article also depicts some regulatory updates along with the patents granted to the inventor for their work on ODD. Overall, a thought of how the different forthcoming of nanotechnologies like nanoparticles and nanomedicine can be used to investigate the frontiers of ODD and treatment can be withdrawn by this article.

中文翻译：

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眼部给药系统的纳米制剂和临床研究亮点：概述。

已经研究了几种眼部药物递送 (ODD) 系统，如水凝胶、微粒、纳米乳剂、微乳剂和脂质体，它们可以控制药物释放并在眼部延迟期间维持治疗水平。虽然通过各种纳米颗粒可以实现针对眼睛的新药物靶向方法。目前在市场上，对于新型纳米眼递送系统以及延长前眼和后眼段递送的疗法的选择和需求较少。本文的主要目的是总结 ODD 中不同纳米和微系统的当前发现和已证实的活动。本文还描述了一些监管更新以及授予发明人在 ODD 上的工作的专利。全面的，