A novel strategy has been devised for the synthesis of pyrrole based acyclo-C-nucleosides, in particular an open-chain sugar substituted pyrrole derivatives by means of the condensation of 2-C-formyl glycals with α-amino acids through an intramolecular azomethine cycloaddition under thermal conditions. The use of cyclic α-amino acids provides the corresponding bicyclic pyrrole derivatives. This is a first report on the synthesis of pyrrole based acyclo-C-nucleosides. 2009 Elsevier Ltd. All rights reserved.

中文翻译：

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用于合成取代吡咯的 2-C-甲酰基聚糖与 α-氨基酸的偶氮甲碱叶立德环加成反应

一种新的策略已被设计用于吡咯的基于acyclo-合成Ç核苷，特别是开链糖通过2-缩合来取代的吡咯衍生物Ç甲酰基烯糖用α-氨基酸通过分子内甲亚胺环加成在热条件下。环状α-氨基酸的使用提供了相应的双环吡咯衍生物。这是基于吡咯acyclo-合成的第一报告Ç核苷。2009 Elsevier Ltd. 保留所有权利。