Cell Biology International ( IF 3.9 ) Pub Date : 2021-08-10 , DOI: 10.1002/cbin.11686 Marcarious M Tantuoyir 1, 2, 3 , Nima Rezaei 1, 4, 5
In response to the commentary article about our recent publication in Cell Biology International (https://doi.org/10.1002/cbin.11516), which states that Hemagglutinin-esterase protein is absent in SARS-Cov2 as reported in Table 2 of our publication, we acknowledge the error and seek for correction. This is largely due to the uncertainties and discoveries about the SARS-COV-2 virus. However, the information provided in our publication was validated by Ravi et al. (2020) but upon critical consideration and extensive reviews of the viral structural proteins, the Hemagglutinin-esterase protein is absent in the SARS-COV-2 viral structure (Astuti & Ysrafil, 2020; Yin, 2020). Therefore, the following correction should be made accordingly:
Protein Name | Binding mechanism | Role |
---|---|---|
Spike protein (S) | Utilizes an N-terminal signal sequence to gain access to the ER (endoplasmic reticulum) | Mediates attachment to host receptors |
Nucleocapsid protein (N) | Binds the viral genome in a beads-on-a-string type conformation | Tethers the viral genome to replicase-transcriptase complex, packages the encapsulated genome into viral particles |
Envelope protein (E) | A transmembrane protein with ion channel activity | Facilitates assembly and release of the virus; involved in ion channel activity |
Membrane protein (M) | Binds to nucleocapsid | Promotes membrane curvature |
中文翻译:
COVID-19 的血清学检测:潜在机会
作为对我们最近在国际细胞生物学(https://doi.org/10.1002/cbin.11516)上发表的评论文章的回应,该文章指出血凝素酯酶蛋白在 SARS-Cov2 中不存在,如我们的表 2 所述出版,我们承认错误并寻求更正。这主要是由于有关 SARS-COV-2 病毒的不确定性和发现。然而,我们出版物中提供的信息已经过 Ravi 等人的验证。( 2020 ) 但在对病毒结构蛋白进行批判性考虑和广泛审查后,SARS-COV-2 病毒结构中不存在血凝素-酯酶蛋白 (Astuti & Ysrafil, 2020 ; Yin, 2020 )。因此,应作如下修正:
蛋白质名称 | 绑定机制 | 角色 |
---|---|---|
刺突蛋白 (S) | 利用 N 端信号序列进入 ER(内质网) | 介导与宿主受体的附着 |
核衣壳蛋白 (N) | 以串珠型构象结合病毒基因组 | 将病毒基因组连接到复制酶-转录酶复合物,将封装的基因组包装成病毒颗粒 |
包膜蛋白 (E) | 具有离子通道活性的跨膜蛋白 | 促进病毒的组装和释放;参与离子通道活动 |
膜蛋白 (M) | 与核衣壳结合 | 促进膜曲率 |