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Serum Neuropeptide Y: A Potential Prognostic Marker of Intracerebral Hemorrhage
Disease Markers ( IF 3.464 ) Pub Date : 2021-08-10 , DOI: 10.1155/2021/7957013
Weiming Sun 1 , Zhenxing Zhang 2 , Xu Feng 2 , Xin Sui 2 , Ye Miao 2
Affiliation  

Objective. Neuropeptide Y (NPY), a 36-amino acid neuromodulator, is mainly secreted by neurons in the central and peripheral nervous systems, which participate in the regulation of a series of physiological processes. However, there are few studies on its correlation with intracranial hemorrhage (ICH). The purpose of this study is to determine whether the serum NPY level is related to the prognosis of ICH. Methods. 364 patients diagnosed with ICH were included in the current study. The demographics, anthropometrics, medical history, clinical severity, and laboratory data are collected. Enzyme-linked immunoassay (ELISA) was used to detect the serum NPY level of each patient upon admission. Three months after the occurrence of ICH, we used the modified Rankin scale (mRS) to evaluate the prognosis of patients, and was defined as a poor prognosis. Results. A total of 364 patients with ICH were included in the study, including 140 patients with a good prognosis and 224 patients with a poor prognosis. Compared with patients with a poor prognosis, ICH patients with a good prognosis have a lower baseline National Institutes of Health Stroke Scale (NIHSS) score () and smaller hematoma volume (). The results of ELISA showed that compared with patients with a poor prognosis, ICH patients with a good prognosis had lower serum NPY levels ( vs.  ng/ml, ). Linear correlation analysis showed that the serum NPY level of ICH patients was significantly positively correlated with the baseline NIHSS score (, ) and hematoma volume (, ). Receiver operating characteristic (ROC) curve analysis showed that the sensitivity of the serum NPY level to predict the prognosis of ICH was 70.9%, the specificity was 72.6%, and the cut-off value was 24.2 ng/ml. Conclusions. The serum NPY level may be used as a predictor of ICH prognosis.

中文翻译:

血清神经肽 Y:脑出血的潜在预后标志物

客观。神经肽Y(NPY)是一种由36个氨基酸组成的神经调节剂,主要由中枢和外周神经系统的神经元分泌,参与一系列生理过程的调节。然而,很少有关于其与颅内出血(ICH)相关性的研究。本研究的目的是确定血清NPY水平是否与ICH的预后相关。方法. 364 名诊断为 ICH 的患者被纳入本研究。收集人口统计学、人体测量学、病史、临床严重程度和实验室数据。入院时采用酶联免疫测定法(ELISA)检测每位患者的血清NPY水平。ICH 发生 3 个月后,我们使用改良 Rankin 量表(mRS)评估患者的预后,并被定义为预后不良。结果。研究共纳入364例ICH患者,其中预后良好140例,不良预后224例。与预后不良的患者相比,预后良好的 ICH 患者的基线美国国立卫生研究院卒中量表(NIHSS)评分较低。)和较小的血肿体积 ()。ELISA结果显示,与预后不良的患者相比,预后良好的ICH患者血清NPY水平较低(对比 纳克/毫升,)。线性相关分析显示,ICH患者血清NPY水平与基线NIHSS评分呈显着正相关(, )和血肿体积 (, )。受试者工作特征(ROC)曲线分析显示,血清NPY水平预测ICH预后的敏感性为70.9%,特异性为72.6%,临界值为24.2 ng/ml。结论。血清 NPY 水平可作为 ICH 预后的预测指标。
更新日期:2021-08-10
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