Objective. This study was aimed at exploring the diagnostic and prognostic value of long noncoding RNA LINC01554 (LINC01554) in epithelial ovarian cancer (EOC) patients. Patients and Methods. The expressions of LINC01554 in 161 EOC patients were analyzed using RT-PCR. The area under the ROC curve (AUC) was used to estimate the effectiveness of LINC01554 for prediction. The chi-square test was performed to explore the association between LINC01554 expressions and clinical characteristics in EOC patients. Kaplan-Meier assays were conducted for the examination of the influence of LINC01554 expression on the overall survival of EOC patients. Multivariate analyses were carried out to further determine prognostic values of LINC01554 expression in EOC patients. Results. LINC01554 expressions were strongly downregulated in EOC specimens compared with matched nontumor specimens (). Importantly, LINC01554 provided a high diagnostic performance for the detection of EOC specimens (; ). Low expression of LINC01554 was distinctly associated with the FIGO stage () and distant metastasis (). The assays of survival data (five years) revealed that the 5-year overall survival of the low LINC01554 expression group was distinctly shorter than that of the high LINC01554 expression group (). Finally, in the multivariate Cox model, LINC01554 expression (, 95% CI: 1.185-4.421, ) was demonstrated to be an independent prognostic factor for overall survival of EOC patients. Conclusions. Our findings suggested that LINC01554 is an important EOC-related lncRNA, providing a potential diagnostic, prognostic biomarker and therapeutic target for EOC patients.

中文翻译：

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长链非编码 RNA LINC01554 作为上皮性卵巢癌诊断和预后预测的新型生物标志物

客观。本研究旨在探索长链非编码 RNA LINC01554 (LINC01554) 在上皮性卵巢癌 (EOC) 患者中的诊断和预后价值。患者和方法。使用 RT-PCR 分析了 161 名 EOC 患者中 LINC01554 的表达。ROC 曲线下面积 (AUC) 用于估计 LINC01554 预测的有效性。进行卡方检验以探索 EOC 患者 LINC01554 表达与临床特征之间的关联。进行 Kaplan-Meier 测定以检查 LINC01554 表达对 EOC 患者总生存期的影响。进行多变量分析以进一步确定 EOC 患者中 LINC01554 表达的预后价值。结果. 与匹配的非肿瘤标本相比，EOC 标本中的 LINC01554 表达强烈下调（）。重要的是，LINC01554 为 EOC 标本的检测提供了高诊断性能（; ）。LINC01554的低表达与FIGO阶段明显相关（)和远处转移 (）。生存数据分析（5 年）显示，LINC01554 低表达组的 5 年总生存期明显短于 LINC01554 高表达组。）。最后，在多变量 Cox 模型中，LINC01554 表达式 (, 95% CI: 1.185-4.421,)被证明是 EOC 患者总生存期的独立预后因素。结论。我们的研究结果表明，LINC01554 是一种重要的 EOC 相关 lncRNA，为 EOC 患者提供了潜在的诊断、预后生物标志物和治疗靶点。