Aims

Describe the local characteristics, methodology and results of the registry of acromegalic patients in Colombia (RAPACO).

Methods

Multicenter, retrospective study based on the registry of acromegalic patients in Colombia: RAPACO. The data collected included: demographics, diagnosis, approximate time of disease evolution, data on weight, height, body mass index (BMI), neck circumference (NC) abdominal circumference (AC) hip circumference (HC) and waist/hip ratio (WHR); clinical and biochemical data at the time of diagnosis, etiology, immunohistochemistry of the tumor and information related to types of treatment. Descriptive analytics were employed.

Results

A total of 201 patients (60% females) with an average age at registration of 49.5 ± 14.6 years and an average time of evolution of the disease of 6.96 ± 4.5 years. Average weight was 75.1 Kg ± 12.98, with an average BMI of 28.11 ± 4.33. The most frequent symptoms mentioned at the time of diagnosis were extremity enlargement and headache. The most frequent comorbidity was arterial hypertension in 50.3% of the cases. 78.6% of cases were caused by macroadenoma. 80.1% received surgical treatment, 77.6% were under medical treatment, of which 95.7% were receiving somatostatin analogues. 26.4% of patients were treated with radiation therapy. Of the patients who received any type of clinical treatment, only 2.5% reported biochemical control at registration.

Conclusion

It is important to recognize the local epidemiological, clinical, biochemical and treatment characteristics in order to assist in further understanding this pathology to implement local measures to improve both the quality of life as well as the prognosis of the patients diagnosed.

中文翻译：

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基于哥伦比亚肢端肥大症患者登记的临床和流行病学特征、发病率和治疗：RAPACO

目标

描述哥伦比亚肢端肥大症患者登记 (RAPACO) 的当地特征、方法和结果。

方法

基于哥伦比亚肢端肥大症患者登记的多中心回顾性研究：RAPACO。收集的数据包括：人口统计、诊断、疾病演变的大致时间、体重、身高、体重指数 (BMI)、颈围 (NC) 腹围 (AC) 臀围 (HC) 和腰/臀比 (WHR) 数据); 诊断时的临床和生化数据、病因学、肿瘤的免疫组织化学以及与治疗类型相关的信息。采用了描述性分析。

结果

共有 201 名患者（60% 为女性），登记时的平均年龄为 49.5 ± 14.6 岁，疾病平均发展时间为 6.96 ± 4.5 年。平均体重为 75.1 Kg ± 12.98，平均 BMI 为 28.11 ± 4.33。诊断时提到的最常见症状是四肢肿大和头痛。在 50.3% 的病例中，最常见的合并症是动脉高血压。78.6%的病例是由大腺瘤引起的。80.1%接受手术治疗，77.6%接受药物治疗，其中95.7%接受生长抑素类似物治疗。26.4% 的患者接受了放射治疗。在接受任何类型临床治疗的患者中，只有 2.5% 的患者在注册时报告了生化控制。

结论

认识当地的流行病学、临床、生化和治疗特征很重要，以帮助进一步了解这种病理学，以实施当地措施，以改善被诊断患者的生活质量和预后。