A randomised controlled trial (RCT) on integrated malaria prevention, which advocates the use of several malaria prevention methods holistically, has been proposed. However, before conducting an RCT, it is recommended that a feasibility study is carried out to provide information to support the main study, particularly for such a complex intervention. Therefore, a feasibility study for an RCT on integrated malaria prevention in Uganda was conducted. The qualitative study carried out in Wakiso District employed focus group discussions (FGDs) and key informant interviews (KIIs) to explore community willingness to participate in the RCT as well as assess stakeholder perspectives on the future study. The participants of the FGDs were community members, while the key informants were selected from malaria stakeholders including Ministry of Health officials, health practitioners, local leaders, district health team members, and community health workers (CHWs). Thematic analysis was employed with the support of NVivo. A total of 12 FGDs and 19 KIIs were conducted. Five main themes emerged from the study: malaria prevention practices related to integrated malaria prevention; preferred malaria prevention methods in the integrated approach; potential challenges of integrated malaria prevention; perspectives on the proposed RCT; and sustainability of integrated malaria prevention. Despite a few methods being employed holistically in the community, insecticide-treated nets were the most widely used and preferred method for malaria prevention mainly because they were provided free by the government. The main challenges in the integrated approach were the high cost of some methods such as house screening, and concerns about the potential side effects of insecticide-based methods such as indoor residual spraying. Participants expressed high willingness to participate in the RCT to promote the use of multiple methods in their households and community. Involvement of CHWs during implementation was proposed as a sustainability strategy for the RCT interventions. There was high willingness to participate in the proposed RCT on integrated malaria prevention. However, high cost and perceived negative health effects from some methods were identified as potential challenges. The type of methods to be included as well as sustainability mechanisms needs to be considered during the design of the RCT.

中文翻译：

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乌干达农村社区的综合疟疾预防：随机对照试验的定性可行性研究

已经提出了一项关于综合疟疾预防的随机对照试验 (RCT)，该试验提倡整体使用几种疟疾预防方法。但是，在进行 RCT 之前，建议进行可行性研究以提供支持主要研究的信息，尤其是对于如此复杂的干预措施。因此，在乌干达开展了一项关于综合疟疾预防的随机对照试验的可行性研究。在 Wakiso 区进行的定性研究采用焦点小组讨论 (FGD) 和关键知情人访谈 (KII) 来探索社区参与 RCT 的意愿，并评估利益相关者对未来研究的看法。FGD 的参与者是社区成员，而关键知情人是从疟疾利益相关者中挑选出来的，包括卫生部官员、卫生从业人员、地方领导人、地区卫生团队成员和社区卫生工作者 (CHW)。在 NVivo 的支持下采用了专题分析。总共进行了 12 次 FGD 和 19 次 KII。研究中出现了五个主要主题：与综合疟疾预防相关的疟疾预防实践；综合方法中首选的疟疾预防方法；疟疾综合预防的潜在挑战；对拟议 RCT 的看法；和疟疾综合预防的可持续性。尽管社区整体采用了一些方法，但经杀虫剂处理的蚊帐是最广泛使用和首选的疟疾预防方法，主要是因为它们由政府免费提供。综合方法的主要挑战是一些方法（例如房屋筛查）的高成本，以及对基于杀虫剂的方法（例如室内滞留喷洒）的潜在副作用的担忧。参与者表示非常愿意参与 RCT，以促进在其家庭和社区中使用多种方法。建议在实施过程中让 CHW 参与作为 RCT 干预措施的可持续性战略。参与拟议的疟疾综合预防随机对照试验的意愿很高。然而，某些方法的高成本和对健康的负面影响被认为是潜在的挑战。在 RCT 的设计过程中需要考虑要包括的方法类型以及可持续性机制。