Temporal Changes in Cognitive Function in Early Recovery Phase of the Stroke,Journal of Stroke & Cerebrovascular Diseases

当前位置： X-MOL 学术 › J. Stroke Cerebrovasc. Dis. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Temporal Changes in Cognitive Function in Early Recovery Phase of the Stroke
Journal of Stroke & Cerebrovascular Diseases ( IF 2.5 ) Pub Date : 2021-08-10 , DOI: 10.1016/j.jstrokecerebrovasdis.2021.106027
Pornpatr A. Dharmasaroja _{1,

2}

Affiliation

Objectives

Only a few studies longitudinally evaluated all cognitive domains after acute stroke. The purpose was to study the changes in cognitive function after acute stroke.

Materials and Methods

Cognitive assessment, using Thai mental state examination (TMSE) and Montreal Cognitive Assessment (MOCA), was performed at the acute stroke, and at 3 and 6 months after stroke. Cognitive domains were evaluated by MOCA subcategory score. TMSE and MOCA were compared at different stages of stroke and in among those with normal cognition (NC), vascular mild cognitive impairment (VMCI) and vascular dementia (VAD).

Results

138 patients were included. At 6 months, 32 patients (23%) had NC. VMCI and VAD were diagnosed in 76 patients (55%), and 30 patients (22%), respectively. Total scores of TMSE and MOCA were higher at 3 months as compared to at the acute stroke (TMSE; 24.85 vs 23.01, p-value <0.001, MOCA; 19.30 vs 16.49, p-value <0.001), and higher TMSE, but not MOCA, at 6 months as compared to at 3 months (TMSE; 25.35 vs 24.85, p-value= 0.021, MOCA;19.04 vs 19.30, p-value= 0.058). Changes in total scores at early stroke were highest in NC. VMCI and VAD patients had cognitive impairment in all cognitive domains.

Conclusions

Cognitive impairment was highest at the acute stroke and improved during early recovery. The greatest rate of improvement occurred within 3 months. Improvement was found in all cognitive domains.

中文翻译：

中风早期恢复阶段认知功能的时间变化

目标

只有少数研究纵向评估了急性卒中后的所有认知领域。目的是研究急性脑卒中后认知功能的变化。

材料和方法

使用泰国精神状态检查 (TMSE) 和蒙特利尔认知评估 (MOCA) 进行认知评估，在急性中风时以及中风后 3 个月和 6 个月进行。认知领域通过 MOCA 子类别评分进行评估。TMSE 和 MOCA 在脑卒中的不同阶段和正常认知 (NC)、血管轻度认知障碍 (VMCI) 和血管性痴呆 (VAD) 的患者中进行了比较。

结果

包括 138 名患者。在 6 个月时，32 名患者 (23%) 患有 NC。分别有 76 名患者 (55%) 和 30 名患者 (22%) 诊断出 VMCI 和 VAD。与急性卒中时相比，3 个月时 TMSE 和 MOCA 的总分更高（TMSE；24.85 对 23.01，p值 <0.001，MOCA；19.30 对 16.49，p值 <0.001）和更高的 TMSE，但不是MOCA，6 个月与 3 个月相比（TMSE；25.35 对 24.85，p值 = 0.021，MOCA；19.04 对 19.30，p值 = 0.058）。NC 中早期卒中总分的变化最高。VMCI 和 VAD 患者在所有认知领域都有认知障碍。