Ophthalmic Plastic and Reconstructive Surgery ( IF 2 ) Pub Date : 2022-03-01 , DOI: 10.1097/iop.0000000000002039 Abanoob F Tadrosse 1 , Marina F Tadrosse , Bishoy M Ezzat , Dina M Sadek , Paul D Langer
Purpose:
To investigate the risk of second primary neoplasms (SPNs) after primary sebaceous carcinoma of the eyelid (SCE).
Methods:
Data on patients diagnosed with primary SCE as their first malignancy were extracted from the Surveillance, Epidemiology, and End Results database from 2000 to 2016. Observed-to-expected ratios of SPNs were calculated to estimate standardized incidence ratios (SIRs). Patients were compared with a reference population (RP) matched for age, gender, and race.
Results:
Five hundred fifty-nine patients with primary SCE were identified, 16% of whom developed SPNs. SCE patients displayed a 61% increased risk of developing SPNs compared with the RP (p < 0.001). Overall, the risk of SPNs of the lungs (SIR = 1.82; p < 0.05), pancreas (SIR = 2.94; p < 0.05), salivary glands (SIR = 41.65; p < 0.001), and skin (SIR = 8.33; p < 0.05) was elevated. Only non-Hispanic Whites were at an increased risk (SIR = 1.51; p < 0.05). Patients 40–54 years old at the time of diagnosis were at the highest risk of developing SPNs compared with the RP (SIR = 3.15; p < 0.05). Women with SCE experienced an increased risk of breast cancer (SIR = 3.6; p < 0.05) and chronic lymphocytic leukemia (SIR = 8.8; p < 0.01).
Conclusion:
SCE patients are more likely to develop SPNs of the lungs, pancreas, salivary gland, and skin than the RP. Forty to fifty-four years old Caucasian patients are at the highest risk. Women are at an increased risk of developing breast malignancies and chronic lymphocytic leukemia. Clinicians should be cognizant of these risks when managing SCE patients.
中文翻译:
眼睑皮脂癌患者的第二原发肿瘤:一项基于人群的研究,2000 年至 2016 年
目的:
调查原发性眼睑皮脂腺癌 (SCE) 后发生第二原发性肿瘤 (SPN) 的风险。
方法:
从 2000 年至 2016 年的监测、流行病学和最终结果数据库中提取了诊断为原发性 SCE 作为首发恶性肿瘤的患者的数据。计算 SPN 的观察与预期比率,以估计标准化发病率 (SIR)。将患者与年龄、性别和种族匹配的参考人群 (RP) 进行比较。
结果:
确定了 559 名原发性 SCE 患者,其中 16% 出现 SPN。与 RP 患者相比,SCE 患者发生 SPN 的风险增加 61% ( p < 0.001)。总体而言,肺部(SIR = 1.82;p < 0.05)、胰腺(SIR = 2.94;p < 0.05)、唾液腺(SIR = 41.65;p < 0.001)和皮肤(SIR = 8.33;p < 0.001)的 SPN 风险 < 0.05) 升高。只有非西班牙裔白人的风险增加(SIR = 1.51;p < 0.05)。与 RP 相比,诊断时年龄为 40-54 岁的患者发生 SPN 的风险最高(SIR = 3.15;p < 0.05)。患有 SCE 的女性患乳腺癌(SIR = 3.6;p < 0.05)和慢性淋巴细胞白血病(SIR = 8.8;p < 0.01)的风险增加。
结论:
SCE 患者比 RP 患者更容易出现肺、胰腺、唾液腺和皮肤 SPN。四十至五十四岁的白人患者风险最高。女性患乳腺恶性肿瘤和慢性淋巴细胞白血病的风险增加。临床医生在管理 SCE 患者时应认识到这些风险。