Glioblastoma multiforme (GBM), the most frequently occurring malignant brain tumor in adults, remains mostly untreatable. Because of the heterogeneity of invasive gliomas and drug resistance associated with the tumor microenvironment, the prognosis is poor, and the survival rate of patients is low. Communication between GBMs and non-glioma cells in the tumor microenvironment plays a vital role in tumor growth and recurrence. Emerging data have suggested that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells-of-origin of gliomas, and SVZ NSC involvement is associated with the progression and recurrence of GBM. This review highlights the interaction between SVZ NSCs and gliomas, summarizes current findings on the crosstalk between gliomas and other non-glioma cells, and describes the links between SVZ NSCs and gliomas. We also discuss the role and mechanism of SVZ NSCs in glioblastoma, as well as the interventions targeting the SVZ and their therapeutic implications in glioblastoma. Taken together, understanding the biological mechanism of glioma-NSC interactions can lead to new therapeutic strategies for GBM.

中文翻译：

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脑室下区神经干细胞在胶质母细胞瘤中的作用和机制。

多形性胶质母细胞瘤 (GBM) 是成人中最常见的恶性脑肿瘤，目前仍然无法治愈。由于侵袭性胶质瘤的异质性和与肿瘤微环境相关的耐药性，预后差，患者生存率低。肿瘤微环境中 GBM 与非神经胶质瘤细胞之间的通讯在肿瘤生长和复发中起着至关重要的作用。新出现的数据表明，脑室下区 (SVZ) 中的神经干细胞 (NSC) 是胶质瘤的起源细胞，SVZ NSC 受累与 GBM 的进展和复发有关。这篇综述强调了 SVZ NSCs 和神经胶质瘤之间的相互作用，总结了目前关于神经胶质瘤和其他非神经胶质瘤细胞之间串扰的发现，并描述了 SVZ NSCs 和神经胶质瘤之间的联系。我们还讨论了 SVZ NSCs 在胶质母细胞瘤中的作用和机制，以及针对 SVZ 的干预措施及其在胶质母细胞瘤中的治疗意义。总之，了解胶质瘤-NSC 相互作用的生物学机制可以为 GBM 带来新的治疗策略。