Current clinical treatment options for symptomatic, partial-thickness rotator cuff tear (sPTRCT) offer only limited potential for true tissue healing and improvement of clinical results. In animal models, injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon tissue. However, it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh, uncultured, autologous, adipose derived regenerative cells (UA-ADRCs). A specific challenge in this regard is that UA-ADRCs cannot be labeled and, thus, not unequivocally identified in the host tissue. Therefore, histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive, immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of UA-ADRCs.

中文翻译：

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干细胞注射后人肌腱修复的第一个免疫组织化学证据：病例报告和文献复习。

目前针对有症状的部​​分厚度肩袖撕裂 (sPTRCT) 的临床治疗选择为真正的组织愈合和临床结果的改善提供了有限的潜力。在动物模型中，从脂肪组织中分离出的成体干细胞注射到肌腱损伤中证明了肌腱组织的组织学再生。然而，尚不清楚在用新鲜的、未培养的、自体的、脂肪来源的再生细胞 (UA-ADRC) 处理的人肌腱中是否也能观察到这种有益作用。这方面的一个具体挑战是 UA-ADRC 不能被标记，因此不能在宿主组织中明确识别。因此，注射 UA-ADRCs 后受伤人肌腱的组织学再生必须使用综合评估，