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Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia
European Journal of Neurology ( IF 5.1 ) Pub Date : 2021-08-10 , DOI: 10.1111/ene.15058
Anuschka Silva-Spínola 1, 2 , Marisa Lima 1, 3, 4 , Maria João Leitão 1 , João Durães 1, 3, 5 , Miguel Tábuas-Pereira 1, 3, 5 , Maria Rosário Almeida 1 , Isabel Santana 1, 3, 5 , Inês Baldeiras 1, 5
Affiliation  

Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated the correlation of both cerebrospinal fluid (CSF) and serum NfL with detailed neuropsychological data and cognitive decline in a cohort of sporadic and familial FTD.

中文翻译:

血清神经丝轻链作为散发性和家族性额颞叶痴呆认知能力下降的替代指标

神经丝轻链 (NfL) 最近被提议作为额颞叶痴呆 (FTD) 的有前途的生物标志物。我们在一组散发性和家族性 FTD 中调查了脑脊液 (CSF) 和血清 NfL 与详细的神经心理学数据和认知能力下降的相关性。
更新日期:2021-08-10
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