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Nanogels as controlled drug release systems for Coenzyme Q10 and Resveratrol for cosmetic application
Journal of Nanoparticle Research ( IF 2.5 ) Pub Date : 2021-08-07 , DOI: 10.1007/s11051-021-05243-z
E. Arroyo 1 , R. Valdez 2 , A. Olivas 2 , J. M. Cornejo-Bravo 3 , M. A. Armenta 4
Affiliation  

Polymeric nanogels have been widely used as drug carrier systems due to their high drug loading capacity and an improved solubility of hydrophobic drugs. Many studies have shown that hydrophobic antioxidants, such as CoQ10 or Resveratrol, might improve healthy skin and be an effective anti-aging treatment by repairing photo-damaged skin. This study was carried out to develop a delivery system based on bio-compatible and water-dispersible nanogels capable of encapsulating Coenzyme Q10 (CoQ10) and Resveratrol. The nanogels are based on Pluronic® P123 coated with polyvinylpyrrolidone plus polyethyleneglycol (P123/PVP-PEG). Their physicochemical properties and morphological characteristics were evaluated in detail, as well as in vitro drug release. These nanogels were able to encapsulate and release Resveratrol and CoQ10 better than pure drugs at skin temperature (32 °C), from 31 to 43 and from 25 to 40%, respectively. The systems exhibited nanometric dimensions and spherical shape shown in the SEM and HRTEM micrographs. The bacterial bioassays studies showed that loaded materials do not affect bacterial growth. In addition, aqueous polymeric dispersions were stable for at least 24 h. The results indicated that the prepared nanogels were water-dispersible, non-toxic in the first tests, and they could be potential candidates for hydrophobic antioxidant release.

Graphical abstract



中文翻译:

纳米凝胶作为化妆品应用中辅酶 Q10 和白藜芦醇的控释系统

聚合物纳米凝胶由于其高载药量和改善的疏水性药物溶解度而被广泛用作药物载体系统。许多研究表明,疏水性抗氧化剂,如辅酶 Q10 或白藜芦醇,可能会改善健康的皮肤,并通过修复光损伤的皮肤成为一种有效的抗衰老治疗方法。本研究旨在开发一种基于生物相容性和水分散性纳米凝胶的递送系统,能够包裹辅酶 Q10 (CoQ10) 和白藜芦醇。纳米凝胶基于涂有聚乙烯吡咯烷酮和聚乙二醇 (P123/PVP-PEG) 的 Pluronic® P123。详细评估了它们的理化性质和形态特征,以及体外药物释放。这些纳米凝胶在皮肤温度 (32 °C) 下能够比纯药物更好地封装和释放白藜芦醇和辅酶 Q10,分别为 31% 至 43% 和 25% 至 40%。该系统在 SEM 和 HRTEM 显微照片中显示出纳米尺寸和球形。细菌生物测定研究表明,加载的材料不会影响细菌的生长。此外,水性聚合物分散体在至少 24 小时内是稳定的。结果表明,制备的纳米凝胶在第一次测试中具有水分散性,无毒,并且它们可能是疏水性抗氧化剂释放的潜在候选者。细菌生物测定研究表明,加载的材料不会影响细菌的生长。此外,水性聚合物分散体在至少 24 小时内是稳定的。结果表明,制备的纳米凝胶在第一次测试中具有水分散性,无毒,并且它们可能是疏水性抗氧化剂释放的潜在候选者。细菌生物测定研究表明,负载材料不会影响细菌生长。此外,水性聚合物分散体在至少 24 小时内是稳定的。结果表明,制备的纳米凝胶在第一次测试中具有水分散性,无毒,并且它们可能是疏水性抗氧化剂释放的潜在候选者。

图形概要

更新日期:2021-08-09
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