Increasing plasma glucose before the development of type 1 diabetes—the TRIGR study,Pediatric Diabetes

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Increasing plasma glucose before the development of type 1 diabetes—the TRIGR study
Pediatric Diabetes ( IF 3.4 ) Pub Date : 2021-08-09 , DOI: 10.1111/pedi.13251
Johnny Ludvigsson ₁ , David Cuthbertson ₂ , Dorothy J Becker ₃ , Olga Kordonouri ₄ , Bärbel Aschemeier ₄ , Daniele Pacaud ₅ , Cheril Clarson _{6,

7} , Jeffrey P Krischer ₂ , Mikael Knip _{8,

9,

10,

11} ,

Affiliation

Crown Princess Victoria Children's Hospital and Div of Pediatrics, Dept of Biomedical and Clinical Sciences, Linköping university, Linköping, Sweden.
Health Informatics Institute, University of South Florida, Tampa, Florida, USA.
Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA.
Diabetes Centre for Children and Adolescents, Kinder- und Jugendkrankenhaus Auf der Bult, Hannover, Germany.
Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, USA.
Department of Paediatrics, University of Western Ontario, London, ON, Canada.
Lawson Health Research Institute, London, ON, Canada.
Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.
Folkhälsan Research Center, Helsinki, Finland.

The β-cell stress hypothesis suggests that increased insulin demand contributes to the development of type 1 diabetes. In the TRIGR trial we set out to assess the profile of plasma glucose and HbA1c before the diagnosis of clinical diabetes compared to nondiabetic children.

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