Abstract

New thiosemicarbazones were synthesized in excellent yield reaction of indole derivatives with thiosemicarbazides. These thiosemicarbazones were reacted with ethyl bromoacetate to produce original heterocyclic-substituted indole derivatives possessing a 4-oxo-thiazolidine group. Analytical IR and NMR spectra and elemental analysis were performed to reveal their structures. The antimicrobial activity of all synthesized compounds was evaluated for antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. Antibacterial screening data showed that two compounds demonstrated activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These preliminary results indicate that some of these newly synthesized compounds show a promising antibacterial potency.

Graphic abstract

中文翻译：

---

吲哚系列新型缩氨基硫脲和噻唑烷酮类化合物的合成及抗菌活性

摘要

在吲哚衍生物与缩氨基硫脲的极好产率反应中合成了新的缩氨基硫脲。这些缩氨基硫脲与溴乙酸乙酯反应生成具有4-氧代-噻唑烷基团的原始杂环取代吲哚衍生物。进行分析IR和NMR光谱以及元素分析以揭示它们的结构。对所有合成化合物的抗菌活性进行了体外抗革兰氏阳性菌和革兰氏阴性菌的抗菌活性评估。抗菌筛选数据显示两种化合物对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌具有活性。. 这些初步结果表明，这些新合成的化合物中的一些显示出有希望的抗菌效力。

图形摘要