Lamotrigine is one of the most important anti-epileptic drugs and is widely used to control seizure. Electrochemical sensors are fast response, easy operation, and low-cost devices which are used for determination of different analysts in low concentrations. Here, a modified carbon paste electrode, based on nanomagnetic core–shell (Fe₃O₄@SiO₂) and reduced graphene oxide has been introduced for electrocatalytic oxidation and determination of lamotrigine. The synthesized nano-composite electrochemical device was first evaluated for its physicochemical characteristics using several analytical methods of FT-IR, XRD, and SEM. The sensor was then tested against its ability for sensitive determination of the lamotrigine in different conditions. Under the optimum conditions, the calibration curve of lamotrigine was linear in the range of 0.001–3 µM, and the detection limit was 0.7 nM. The as-prepared electrochemical sensor was also successfully used for quantification of the lamotrigine in tablet and plasma samples.

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中文翻译：

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基于改性碳糊电极的拉莫三嗪灵敏电化学传感器

拉莫三嗪是最重要的抗癫痫药物之一，被广泛用于控制癫痫发作。电化学传感器响应速度快、操作简单、成本低，可用于不同分析人员的低浓度测定。在这里，一种基于纳米磁性核壳（Fe ₃ O ₄ @SiO ₂) 和还原氧化石墨烯已被引入用于电催化氧化和测定拉莫三嗪。首先使用 FT-IR、XRD 和 SEM 的几种分析方法评估合成的纳米复合电化学装置的理化特性。然后测试该传感器在不同条件下灵敏测定拉莫三嗪的能力。在最佳条件下，拉莫三嗪的校准曲线在0.001-3 µM范围内呈线性，检出限为0.7 nM。所制备的电化学传感器也成功地用于定量片剂和血浆样品中的拉莫三嗪。

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