Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the progression of acute and chronic kidney damage and the recovery of allograft kidney function by regulating the BMP and Wnt signaling pathways. Moreover, USAG-1 has been found to be involved in the process of T cell immune response, and its ability to inhibit germinal center activity and reduce humoral immunity is of great significance for the treatment of autoimmune nephropathy and antibody-mediated rejection (AMR) after renal transplantation. This article summarizes the many advances made regarding the roles of USAG-1 in the progression of kidney disease and outlines potential treatments.

中文翻译：

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肾脏疾病进展中的子宫致敏相关基因1

子宫致敏相关基因-1 (USAG-1) 最初被确定为在致敏大鼠子宫内膜中优先表达的分泌蛋白，已被确定可调节骨形态发生蛋白 (BMP) 和 Wnt 表达，从而在肾脏疾病中发挥重要作用。USAG-1 通过调节 BMP 和 Wnt 信号通路影响急性和慢性肾损伤的进展以及同种异体肾功能的恢复。此外，已发现USAG-1参与了T细胞免疫反应的过程，其抑制生发中心活性和降低体液免疫的能力对于治疗自身免疫性肾病和抗体介导的排斥反应（AMR）具有重要意义。肾移植后。