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Association of Sputum Neutrophil Extracellular Trap Subsets With IgA Anti–Citrullinated Protein Antibodies in Subjects at Risk for Rheumatoid Arthritis
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2021-08-09 , DOI: 10.1002/art.41948
Yuko Okamoto 1 , Stephanie Devoe 2 , Nickie Seto 3 , Valerie Minarchick 2 , Timothy Wilson 2 , Heather M Rothfuss 4 , Michael P Mohning 5 , Jaron Arbet 2 , Miranda Kroehl 2 , Ashley Visser 2 , Justin August 2 , Stacey M Thomas 5 , Laura Lenis Charry 2 , Chelsie Fleischer 2 , Marie L Feser 2 , Ashley A Frazer-Abel 2 , Jill M Norris 2 , Brian D Cherrington 4 , William J Janssen 5 , Mariana J Kaplan 3 , Kevin D Deane 2 , V Michael Holers 2 , M Kristen Demoruelle 2
Affiliation  

Mechanisms leading to anti–citrullinated protein antibody (ACPA) generation in rheumatoid arthritis (RA) are hypothesized to originate in the lung. We undertook this study to understand associations between neutrophil extracellular trap (NET) formation in the lung and local ACPA generation in subjects at risk of developing RA.

中文翻译:

类风湿关节炎风险受试者中痰中性粒细胞胞外陷阱亚群与 IgA 抗瓜氨酸蛋白抗体的关联

假设类风湿性关节炎 (RA) 中产生抗瓜氨酸蛋白抗体 (ACPA) 的机制起源于肺。我们进行了这项研究,以了解肺中中性粒细胞胞外陷阱 (NET) 形成与有发展为 RA 风险的受试者的局部 ACPA 生成之间的关联。
更新日期:2021-08-09
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