ABSTRACT

A 12-year-old male being treated for a high-risk relapsed T-acute lymphoblastic leukemia presented progressive weakness and numbness of both legs after having received a chemotherapy regimen that included bortezomib. Diagnosis of acute Guillain-Barré syndrome-like inflammatory demyelinating polyneuropathy was made following clinical examination, cerebrospinal fluid analysis, electrodiagnostic studies, magnetic resonance imaging, and serum immunoglobulin antibodies to anti-ganglioside. Intravenous immunoglobulin treatment was started, resulting in complete clinical recovery. Although in rare cases, Guillain-Barré syndrome after bortezomib therapy has been reported; this paper suggests that GBS may occur when bortezomib is administered and high‑dose intravenous immunoglobulin lead to a resolution of the symptoms.

摘要

一名 12 岁男性正在接受高危复发性 T 型急性淋巴细胞白血病治疗，在接受包括硼替佐米在内的化疗方案后，双腿出现进行性虚弱和麻木。在临床检查、脑脊液分析、电诊断研究、磁共振成像和血清抗神经节苷脂免疫球蛋白抗体后，诊断为急性格林-巴利综合征样炎症性脱髓鞘性多发性神经病。开始静脉注射免疫球蛋白治疗，临床完全康复。尽管在极少数情况下，有报道硼替佐米治疗后的格林-巴利综合征；本文表明，当给予硼替佐米并且大剂量静脉注射免疫球蛋白导致症状消退时，可能会发生 GBS。