The synthesis of stimuli-responsive amphiphilic dendrimers consisting of two or three hydrophobic octadecyl groups linked to either a second or third generation hydrophilic polylysine dendron through disulfide linkage is reported. The polylysine dendrimers functionalized with four or eight tert-butyloxycarbonyl (Boc)-protected amino groups are characterized by ¹H NMR spectroscopy and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. With the positively charged versions generated by removing the Boc groups, their ability to form spherical micelles that can be readily disassembled in the presence of glutathione (GSH) is demonstrated. The self-assembly behavior is monitored by scanning electron microscopy (SEM) and dynamic light scattering (DLS). The amphiphilic dendritic systems containing cleavable disulfide linkage serve as key building blocks for generating stimuli-responsive supramolecular architectures.

中文翻译：

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刺激响应两亲树枝状聚合物的合成与自组装

报告了刺激响应性两亲树枝状大分子的合成，该树枝状大分子由两个或三个疏水性十八烷基通过二硫键连接到第二代或第三代亲水性聚赖氨酸树枝状化合物组成。用四个或八个叔丁氧羰基 (Boc) 保护的氨基官能化的聚赖氨酸树枝状聚合物的特征在于¹H NMR 光谱和基质辅助激光解吸电离飞行时间 (MALDI-TOF) 质谱。通过去除 Boc 基团产生带正电荷的版本，证明了它们形成球形胶束的能力，这些胶束在谷胱甘肽 (GSH) 存在下可以很容易地分解。自组装行为通过扫描电子显微镜 (SEM) 和动态光散射 (DLS) 进行监测。含有可切割二硫键的两亲树突系统是产生刺激响应超分子结构的关键构建块。