Spexin (SPX) is a 14 aa peptide discovered in 2007 using bioinformatics methods. SPX inhibits food intake and regulates lipid, and carbohydrate metabolism. Here, we evaluate the ability of SPX at improving metabolic control and liver function in obese and type 2 diabetic animals. The effects of 30 days SPX treatment of mice with experimentally induced obesity (DIO) or type 2 diabetes (T2DM) on serum glucose and lipid levels, insulin sensitivity and hormonal profile (insulin, glucagon, adiponectin, leptin, TNF alpha, IL-6 and IL-1β) are characterized. In addition, alterations of hepatic lipid and glycogen contents are evaluated. We report that SPX decreases body weight in healthy and DIO mice, and reduces lipid content in all three animal groups. SPX improves insulin sensitivity in DIO and T2DM animals. In addition, SPX modulates hormonal and metabolic profile by regulating the concentration of adiponectin (concentration increase) and leptin (concentration decrease) in the serum blood of DIO and T2DM mice. Lastly, SPX decreases lipid content as well as IL-6 and TNF-α protein levels in liver of DIO and T2DM mice, and reduces IL-6 and TNF-alpha concentrations in the serum derived from T2DM mice. Based on our results, we conclude that SPX could be involved in the development of obesity and type 2 diabetes mellitus and it can be further evaluated as a potential target for therapy of DIO and T2DM.

Spexin (SPX) 是一种 14 个氨基酸的肽，于 2007 年使用生物信息学方法发现。SPX 抑制食物摄入并调节脂质和碳水化合物代谢。在这里，我们评估了 SPX 在改善肥胖和 2 型糖尿病动物的代谢控制和肝功能方面的能力。SPX 治疗实验性肥胖 (DIO) 或 2 型糖尿病 (T2DM) 小鼠对血清葡萄糖和血脂水平、胰岛素敏感性和激素谱（胰岛素、胰高血糖素、脂联素、瘦素、TNF α、IL-6）的影响和 IL-1β) 进行了表征。此外，评估肝脂质和糖原含量的变化。我们报告 SPX 降低了健康和 DIO 小鼠的体重，并降低了所有三个动物组的脂质含量。SPX 提高了 DIO 和 T2DM 动物的胰岛素敏感性。此外，SPX 通过调节 DIO 和 T2DM 小鼠血清中脂联素（浓度增加）和瘦素（浓度降低）的浓度来调节激素和代谢谱。最后，SPX 降低了 DIO 和 T2DM 小鼠肝脏中的脂质含量以及 IL-6 和 TNF-α 蛋白水平，并降低了 T2DM 小鼠血清中的 IL-6 和 TNF-α 浓度。根据我们的结果，我们得出结论，SPX 可能参与肥胖和 2 型糖尿病的发展，并且可以进一步评估它作为治疗 DIO 和 T2DM 的潜在目标。并降低 T2DM 小鼠血清中的 IL-6 和 TNF-α 浓度。根据我们的结果，我们得出结论，SPX 可能参与肥胖和 2 型糖尿病的发展，并且可以进一步评估它作为治疗 DIO 和 T2DM 的潜在目标。并降低 T2DM 小鼠血清中的 IL-6 和 TNF-α 浓度。根据我们的结果，我们得出结论，SPX 可能参与肥胖和 2 型糖尿病的发展，并且可以进一步评估它作为治疗 DIO 和 T2DM 的潜在目标。