当前位置: X-MOL 学术Cancer Cell › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Is resistance to targeted therapy in cancer inevitable?
Cancer Cell ( IF 50.3 ) Pub Date : 2021-08-09 , DOI: 10.1016/j.ccell.2021.07.013
Lorey K Smith 1 , Karen E Sheppard 2 , Grant A McArthur 1
Affiliation  

Resistance to targeted therapies is a major challenge in cancer care and occurs via genetic and non-genetic mechanisms. In this issue of Cancer Cell, Marin-Bejar et al. demonstrate that melanomas recurrently select genetic or non-genetic resistance trajectories and that targeting neural crest stem cell-like cells prevents non-genetic, but not genetic, resistance.



中文翻译:

癌症靶向治疗的耐药性是否不可避免?

对靶向治疗的抵抗是癌症治疗中的一个主要挑战,通过遗传和非遗传机制发生。在本期《癌细胞》中,Marin-Bejar 等人。证明黑色素瘤反复选择遗传或非遗传抗性轨迹,并且靶向神经嵴干细胞样细胞可防止非遗传性而非遗传性抗性。

更新日期:2021-08-09
down
wechat
bug