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The promise and peril of KRAS G12C inhibitors
Cancer Cell ( IF 50.3 ) Pub Date : 2021-08-09 , DOI: 10.1016/j.ccell.2021.07.011
Amanda R Moore 1 , Shiva Malek 1
Affiliation  

RAS mutant tumors have been largely refractory to therapies until now. Recent findings published in the New England Journal of Medicine show that sotorasib provides clinical benefit for KRAS p.G12C-mutated non-small-cell lung cancer (NSCLC) and provide mechanistic insights into acquired resistance to KRASG12C-specific inhibition.



中文翻译:

KRAS G12C抑制剂的前景和危险

迄今为止,RAS突变肿瘤在很大程度上对治疗无效。最近发表在《新英格兰医学杂志》上的研究结果表明,索托拉西为KRAS p.G12C 突变的非小细胞肺癌 (NSCLC) 提供了临床益处,并提供了对 KRAS G12C特异性抑制获得性耐药的机制见解。

更新日期:2021-08-09
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