Two biphenyl-type neolignans with a rare dibenzofuran skeleton, including a new one piyunneolignan A (1) and a known one piperneolignan D (2), together with a new sesquiterpenoid piyunin A (3), were isolated from the leaves and twigs of Piper yunnanense. Their structures were established on the basis of comprehensive spectroscopic data analysis and electronic circular dichroism (ECD) calculation. Piyunneolignan A (1) featured a rare C-2−C-2′/C-3−O−C-3′ linkage. Compounds 1–3 were evaluated for their antimicrobial and cytotoxic activities against a panel of bacteria, fungi, and human cancer cell lines, respectively.

中文翻译：

---

云南派的新木脂素和倍半萜类化合物

从Piper的叶子和枝条中分离到了两种具有稀有二苯并呋喃骨架的联苯型新木脂素，包括一个新的piyunneolignan A ( 1 ) 和一个已知的pipereolignan D ( 2 )，以及一个新的倍半萜类piyunin A ( 3 )。云南人。它们的结构是在综合光谱数据分析和电子圆二色性（ECD）计算的基础上建立的。Piyunneolignan A ( 1 ) 具有罕见的 C-2-C-2'/C-3-O-C-3' 连接。化合物1 - 3为对细菌，真菌的人癌细胞系分别是面板，并且，它们的抗微生物和细胞毒活性进行评价。