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A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines
Chemistry - A European Journal ( IF 4.3 ) Pub Date : 2021-08-08 , DOI: 10.1002/chem.202102254
Carlos Lázaro-Milla 1 , Pedro Almendros 2
Affiliation  

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO2CF3 groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

中文翻译:

一种便捷的正式[4+2]杂环化路线制备双(三氟甲基)四氢喹啉

我们报道了一种带有一个或两个SO 2 CF 3基团的新型喹啉衍生物的可持续和高效合成。该方案不含金属、催化剂和辐射,涉及使用容易获得且稳定的前体,并避免副产物的形成。此外,该过程的温和条件允许广泛的官能团的耐受性。
更新日期:2021-09-24
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