MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

中文翻译：

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MYC：一种对血液恶性肿瘤具有预后和治疗意义的多用途癌基因

MYC癌基因是一种转录因子，具有多种功能，影响细胞周期、细胞凋亡、DNA损伤反应和造血等细胞活动。由于 MYC 的多功能性，其表达受到多个水平的调控。这种癌基因的失调会导致多种癌症。这篇综述总结了 MYC 的调节和 MYC 调节细胞功能的机制及其在血液系统恶性肿瘤中的意义。此外，我们还讨论了可能有益于治疗血液恶性肿瘤的潜在 MYC 抑制剂。