Abstract

With the rapid development of industry and transportation in China, the incidence rate of open fracture caused by high energy injuries such as traffic accidents and falling height is increasing year by year. Based on the above background, the purpose of this paper is to study the application of ZnO nano materials with different dimensions in the rehabilitation of patients with limb fracture injury. In order to further solve the problem of limb fracture rehabilitation, zinc oxide nanomaterials are applied to fracture rehabilitation in this paper. The application of zinc oxide nanomaterials in fracture rehabilitation is realized by its strong antibacterial, high-efficiency stability and rich and colorful structure. In this paper, we propose to use the unique physical and chemical properties of ZnO nanomaterials to prepare artificial bone, bone cement, external fixation with good osteogenic performance and antibacterial performance, and carry antibiotics for the treatment of open fracture infection and bone defect. During the experiment, compared with other materials, the infection rate of external fixation was only 63%, and the inflammation index of artificial bone was only 2 mg/dl, which was far less than other materials. Moreover, using the excellent plasticity of ZnO nanomaterials, the oriented ZnO nanotube films were prepared, and the effect of inhibiting scar formation was confirmed through experimental research. In this paper, the unique physical, chemical and biological characteristics of zinc oxide nanomaterials were used to creatively introduce them into the treatment of infectious bone defect and injury rehabilitation caused by limb fracture. Through a series of in vitro and animal in vivo experiments, it was proved that zinc oxide nanomaterials can be used as ideal materials for the treatment of infectious bone defect, which provides new zinc oxide nanomaterials to solve clinical problems A new way of thinking.

摘要

随着我国工业和交通运输业的快速发展，交通事故、高处坠落等高能量损伤引起的开放性骨折发生率逐年上升。基于上述背景，本文旨在研究不同尺寸的ZnO纳米材料在四肢骨折损伤患者康复中的应用。为了进一步解决肢体骨折康复问题，本文将氧化锌纳米材料应用于骨折康复治疗。氧化锌纳米材料以其强抗菌性、高效稳定性和丰富多彩的结构实现了在骨折康复中的应用。在本文中，我们提出利用ZnO纳米材料独特的物理和化学性质来制备人造骨，骨水泥，具有良好成骨性能和抗菌性能的外固定物，携带抗生素治疗开放性骨折感染和骨缺损。实验过程中，与其他材料相比，外固定器的感染率仅为63%，人造骨的炎症指数仅为2mg/dl，远低于其他材料。此外，利用ZnO纳米材料优异的可塑性制备了取向ZnO纳米管薄膜，并通过实验研究证实了其抑制疤痕形成的效果。本文利用氧化锌纳米材料独特的物理、化学和生物学特性，创造性地将其引入治疗感染性骨缺损及肢体骨折引起的损伤康复。