ABSTRACT

Introduction

The Development of the SARS-CoV-2 virus vaccine and its update on an ongoing pandemic is the first subject of the world health agenda.

Areas covered

First, we will scrutinize the biological features of the measles virus (MV), variola virus (smallpox virus), influenza virus, and their vaccines to compare them with the SARS-CoV-2 virus and vaccine. Next, we will discuss the statistical details of measuring the effectiveness of an improved vaccine.

Expert opinion

Amidst the pandemic, we ought to acknowledge our prior experiences with respiratory viruses and vaccines. In the planning stage of observational Phase-III vaccine effectiveness studies, the sample size, sampling method, statistical model, and selection of variables are crucial in obtaining high-quality and valid results.

中文翻译：

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Sars-Cov-2 病毒和疫苗接种；生物学和统计框架

摘要

介绍

SARS-CoV-2 病毒疫苗的开发及其对持续大流行的更新是世界卫生议程的第一个主题。

覆盖区域

首先，我们将仔细检查麻疹病毒（MV）、天花病毒（天花病毒）、流感病毒及其疫苗的生物学特征，将它们与 SARS-CoV-2 病毒和疫苗进行比较。接下来，我们将讨论衡量改进疫苗有效性的统计细节。

专家意见

在大流行中，我们应该承认我们之前在呼吸道病毒和疫苗方面的经验。在观察性 III 期疫苗有效性研究的规划阶段，样本量、抽样方法、统计模型和变量的选择对于获得高质量和有效的结果至关重要。