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Multifunctional plant virus nanoparticles in the next generation of cancer immunotherapies
Seminars in Cancer Biology ( IF 14.5 ) Pub Date : 2021-08-08 , DOI: 10.1016/j.semcancer.2021.07.018
Mehdi Shahgolzari 1 , Hassan Dianat-Moghadam 2 , Steven Fiering 3
Affiliation  

Plant virus nanoparticles (PVNPs) have inherent immune stimulatory ability, and have been investigated as immune adjuvants to stimulate an anti-tumor immune response. The combination of immune stimulation, nanoparticle structure and the ability to deliver other therapeutic molecules provides a flexible platform for cancer immunotherapy. Researching multifunctional PVNPs and their modification will generate novel reagents for cancer immunotherapy. Here we review the properties of PVNPs, and their potential for clinical utilization to activate anti-tumor innate and lymphoid immune responses. PVNP have potential utility for cancer immunotherapy as vaccine adjuvant, and delivery systems for other reagents as mono immunotherapy or combined with other immunotherapies. This review outlines the potential and challenges in developing PVNPs as cancer immunotherapy reagents.



中文翻译:

下一代癌症免疫疗法中的多功能植物病毒纳米粒子

植物病毒纳米颗粒 (PVNPs) 具有固有的免疫刺激能力,并已被研究作为免疫佐剂来刺激抗肿瘤免疫反应。免疫刺激、纳米颗粒结构和递送其他治疗分子的能力的结合为癌症免疫治疗提供了一个灵活的平台。研究多功能 PVNPs 及其修饰将产生用于癌症免疫治疗的新型试剂。在这里,我们回顾了 PVNPs 的特性,以及它们在临床上用于激活抗肿瘤先天免疫和淋巴免疫反应的潜力。PVNP 具有作为疫苗佐剂用于癌症免疫治疗的潜在效用,以及作为单一免疫疗法或与其他免疫疗法联合用于其他试剂的递送系统。

更新日期:2021-08-09
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