Supercritical CO₂ (scCO₂) technology is used here as an efficient method to assist in the preparation of a cutaneous polymeric formulation based on drug containing metal-organic framework composites. The supercritical fluid is used in three steps: (i) as a drying agent for the nanosized mesoporous matrix, (ii) as the impregnation vector of a topical antibiotic drug, and (iii) as a plasticizing and foaming fluid to obtain dispersions of the hybrid material into a biocompatible polymer, e.g., the macroporous patch. The materials were characterized using solid state techniques. The drug delivery and permeation profiles of the patches were investigated applying in vitro and ex vivo tests by using porcine skin. These analyses suggest that scCO₂ impregnation is an easy and fast strategy to prepare composite devices able to progressively release and diffuse the incorporated drug throughout the skin, paving the way to efficiently prepare cutaneous devices for topical or systemic therapies.

超临界 CO ₂ (scCO ₂ ) 技术在此被用作一种有效的方法来帮助制备基于含药物的金属有机骨架复合材料的皮肤聚合物制剂。超临界流体分三个步骤使用：（i）作为纳米介孔基质的干燥剂，（ii）作为局部抗生素药物的浸渍载体，以及（iii）作为增塑和发泡流体以获得分散体将混合材料转化为生物相容性聚合物，例如大孔贴片。使用固态技术表征材料。应用体外和离体研究了贴剂的药物递送和渗透特性使用猪皮进行测试。这些分析表明，scCO ₂浸渍是一种简单快速的制备复合装置的策略，能够逐渐释放和扩散整个皮肤中的药物，为有效制备用于局部或全身治疗的皮肤装置铺平道路。