Abstract

Reference intervals that indicate the anticipated results of clinical chemistry parameters in a healthy background population are essential for the proper interpretation of laboratory data. In the present study, we analysed major trace elements in blood samples from 400 randomly selected members of the general Danish population. Reference intervals were established for trace elements in both whole blood and serum, and associations with major plasma transport proteins were investigated. In the case of a statistically significant correlation, a corresponding protein-adjusted reference interval was established for comparison with the unadjusted interval. While several trace elements correlated with albumin, ferritin and transferrin, the overall impact of transport proteins was minor and resulted in only marginal changes in the reference intervals. In conclusion, the updated reference intervals for trace elements can be employed without adjusting for plasma protein concentrations.

摘要

指示健康背景人群中临床化学参数预期结果的参考区间对于正确解释实验室数据至关重要。在本研究中，我们分析了来自丹麦普通人群的 400 名随机选择成员的血液样本中的主要微量元素。为全血和血清中的微量元素建立了参考区间，并研究了与主要血浆转运蛋白的关联。在具有统计学显着相关性的情况下，建立相应的蛋白质调整参考区间以与未调整区间进行比较。虽然几种微量元素与白蛋白、铁蛋白和转铁蛋白相关，但转运蛋白的总体影响很小，仅导致参考区间的微小变化。