Abstract

Methadone (MTD) is a synthetic analgesic drug used for treating opioid dependence and effectively used clinically for patients with severe pain. The abuse of MTD may lead to poisoning, disorder in the central nervous system and even death. The regular monitoring of MTD in biological matrices including serum, plasma and urine samples is an effective way to control abuse of MTD. In this manner, the selection of analytical monitoring of MTD in biological matrices is of paramount importance. This study was conducted to review high-performance liquid chromatography (HPLC) techniques carried out on MTD and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in the biological samples during 2015–June 2021.

摘要

美沙酮（MTD）是一种合成镇痛药，用于治疗阿片类药物依赖，临床上有效用于严重疼痛患者。滥用MTD可能导致中毒、中枢神经系统紊乱甚至死亡。定期监测包括血清、血浆和尿液样本在内的生物基质中的 MTD 是控制 MTD 滥用的有效方法。通过这种方式，选择生物基质中 MTD 的分析监测至关重要。本研究旨在回顾 2015 年至 2021 年 6 月期间对生物样品中的 MTD 及其主要代谢物 2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷 (EDDP) 进行的高效液相色谱 (HPLC) 技术.