Abstract

Context

Streblus asper Lour. (Moraceae) is used for the treatment of different ailments, including diabetes, and requires scientific validation.

Objective

The study evaluates antidiabetic effects, antioxidant potential, and cytotoxicity of leaf and bark extracts of S. asper.

Materials and methods

Antidiabetic effects were assessed by inducing diabetes in Wistar albino rats (n = 5, six groups included 30 rats) by injecting alloxan [0.25 mg/kg body weight (bw)] intraperitoneally, and efficacy of methanol extracts of leaf and bark, and aqueous extract of leaves were evaluated by oral administration of 300 mg/kg bw of extracts for 3 weeks. Glibenclamide (Dibenol™) was used as a control (10 mg/kg bw). Antioxidant properties were examined by DPPH free radical scavenging activity, and cytotoxicity was investigated using a brine shrimp lethality assay.

Results

Methanol extracts of leaves and bark, and the aqueous extract of leaves of S. asper, caused significant reductions in blood glucose levels in diabetic rats of 36.83, 70.33, and 52.71%, respectively, after 21 days of treatment. IC₅₀ values in DPPH radical scavenging assessment for those extracts were 58.92, 88.54, and 111.36 µg/mL, respectively. LC₅₀ values for brine shrimp lethality for the extracts were 173.80, 32.36, and 3235.9 µg/mL, respectively.

Discussion and conclusions

The methanol bark extract of S. asper showed significant antidiabetic activity. This study will significantly contribute to establishing the plant as an alternative medicinal resource for rural populations of Bangladesh and provides an opportunity for further research to identify the primary active compound(s) and establish new drug candidates.

中文翻译：

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Streblus asper 减轻大鼠四氧嘧啶诱导的糖尿病，并表现出抗氧化和细胞毒性作用

摘要

语境

Streblus asper Lour。（桑科）用于治疗不同的疾病，包括糖尿病，需要科学验证。

客观的

该研究评估了S. asper的叶和树皮提取物的抗糖尿病作用、抗氧化潜力和细胞毒性。

材料和方法

 通过腹膜内注射四氧嘧啶 [0.25 mg/kg 体重 (bw)]诱导 Wistar 白化大鼠 ( n = 5, 6 组包括 30 只大鼠) 的糖尿病效果，以及叶和树皮的甲醇提取物和水通过口服 300 mg/kg bw 的提取物 3 周来评估叶子的提取物。格列本脲 (Dibenol™) 用作对照 (10 mg/kg bw)。通过 DPPH 自由基清除活性检查抗氧化特性，并使用盐水虾致死率测定法研究细胞毒性。

结果

叶子和树皮的甲醇提取物以及S. asper叶子的水提取物在处理 21 天后，分别导致糖尿病大鼠的血糖水平显着降低 36.83%、70.33% 和 52.71%。这些提取物在 DPPH 自由基清除评估中的IC ₅₀值分别为 58.92、88.54 和 111.36 µg/mL。提取物的盐水虾致死率的LC ₅₀值分别为 173.80、32.36 和 3235.9 µg/mL。

讨论和结论

S. asper的甲醇树皮提取物显示出显着的抗糖尿病活性。这项研究将极大地促进将该植物确立为孟加拉国农村人口的替代药用资源，并为进一步研究以确定主要活性化合物和建立新的候选药物提供机会。