Objective Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although the direction of effect differs. We assessed CCL-2 serum levels in a longitudinal cohort to clarify this association, combined with genetic data to elucidate the regulatory role of CCL-2 in T1D pathogenesis.

中文翻译：

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3p21.31 基因座通过 CCR2/CCL2 通路促进进展为 1 型糖尿病

目的多项横断面和纵向研究表明，趋化因子配体 2 (CCL-2) 的血清水平与 1 型糖尿病 (T1D) 相关，尽管作用方向不同。我们在纵向队列中评估了 CCL-2 血清水平以阐明这种关联，并结合遗传数据阐明 CCL-2 在 T1D 发病机制中的调节作用。