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Quantitative psychopathology of interictal psychosis in epilepsy; interaction between epilepsy-related and psychosis-general effects
Epilepsy & Behavior ( IF 2.6 ) Pub Date : 2021-08-07 , DOI: 10.1016/j.yebeh.2021.108214
Masumi Ito 1 , Naoto Adachi 2 , Mitsutoshi Okazaki 3 , Koichiro Hara 4 , Takuya Adachi 5 , Ryoji Matsubara 6 , Masanori Sekimoto 7 , Masaaki Kato 7 , Teiichi Onuma 7
Affiliation  

Objective

There is a historical debate whether psychopathology of epilepsy psychosis is unique to epilepsy or common to other psychoses. However, a large comprehensive studies on this issue are scarce. To clarify the characteristics of interictal psychosis (IIP), we evaluated psychopathology quantitatively.

Methods

This study included 150 patients with IIP (epilepsy+/psychosis+), 187 patients with schizophrenia (SC: epilepsy−/psychosis+), 182 patients with epilepsy (EP: epilepsy+/psychosis−), and 172 non-clinical individuals (NC: epilepsy−/psychosis−). The IIP group comprised 127 chronic and 23 brief psychoses. Age, sex, and years of education, onset and duration of psychosis, and onset and duration of epilepsy were matched among the groups. The psychopathology was evaluated using the 16-item Brief Psychiatric Rating Scale (BPRS), which comprises three symptom factors namely negative symptoms (NS), positive symptoms (PS), and anxiety-depressive symptoms (ADS).

Results

For overall 16-BPRS and NS factor scores, there were significant interactions between epilepsy-related (epilepsy+/−) and psychosis-general (psychosis+/−) effects. The EP exhibited higher scores than did the NC, whereas the IIP exhibited lower scores than did the SC. For PS and ADS factor scores, the IIP and SC exhibited a significant psychosis-general effect. Chronic IIP was associated with more serious psychopathologies than was brief IIP. However, limited with chronic IIP, there was a significant interaction between epilepsy-related and psychosis-general effects on the overall 16-BPRS and NS factor scores.

Conclusion

These findings demonstrate the first large quantitative evidence on the unique psychopathology of IIP which has been only narratively described. The psychopathology is associated with the interaction between epilepsy-related and psychosis-general effects.



中文翻译:

癫痫发作间期精神病的定量精神病理学;癫痫相关效应和精神病一般效应之间的相互作用

客观的

癫痫精神病的精神病理学是癫痫独有的还是其他精神病共有的,存在历史争论。然而,关于这个问题的大型综合研究很少。为了阐明发作间期精神病 (IIP) 的特征,我们定量评估了精神病理学。

方法

该研究包括 150 名 IIP(癫痫+/精神病+)患者、187 名精神分裂症患者(SC:癫痫-/精神病+)、182 名癫痫患者(EP:癫痫+/精神病-)和 172 名非临床个体(NC:癫痫- /精神病-)。IIP 组包括 127 名慢性精神病和 23 名短暂精神病。年龄、性别和受教育年限、精神病的发作和持续时间以及癫痫的发作和持续时间在各组之间匹配。使用 16 项简要精神病学评定量表 (BPRS) 评估精神病理学,该量表包括三个症状因素,即阴性症状 (NS)、阳性症状 (PS) 和焦虑抑郁症状 (ADS)。

结果

对于总体 16-BPRS 和 NS 因子评分,癫痫相关(癫痫+/-)和精神病一般(精神病+/-)影响之间存在显着的相互作用。EP 的得分高于 NC,而 IIP 的得分低于 SC。对于 PS 和 ADS 因子评分,IIP 和 SC 表现出显着的精神病一般效应。与短暂的 IIP 相比,慢性 IIP 与更严重的精神病理学有关。然而,受限于慢性 IIP,癫痫相关和精神病对整体 16-BPRS 和 NS 因子评分的影响之间存在显着的相互作用。

结论

这些发现证明了 IIP 独特的精神病理学的第一个大型定量证据,该证据仅被叙述性地描述。精神病理学与癫痫相关效应和精神病一般效应之间的相互作用有关。

更新日期:2021-08-09
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