BACKGROUND:The blood flow in the human artery has been a subject of sincere interest due to its prime importance linked with human health. The hemodynamic study has revealed an essential aspect of blood flow that eventually proved to be paramount to make a correct decision to treat patients suffering from cardiac disease. OBJECTIVE:The current study aims to elucidate the two-way fluid-structure interaction (FSI) analysis of the blood flow and the effect of stenosis on hemodynamic parameters. METHODS:A patient-specific 3D model of the left coronary artery was constructed based on computed tomography (CT) images. The blood is assumed to be incompressible, homogenous, and behaves as Non-Newtonian, while the artery is considered as a nonlinear elastic, anisotropic, and incompressible material. Pulsatile flow conditions were applied at the boundary. Two-way coupled FSI modeling approach was used between fluid and solid domain. The hemodynamic parameters such as the pressure, velocity streamline, and wall shear stress were analyzed in the fluid domain and the solid domain deformation. RESULTS:The simulated results reveal that pressure drop exists in the vicinity of stenosis and a recirculation region after the stenosis. It was noted that stenosis leads to high wall stress. The results also demonstrate an overestimation of wall shear stress and velocity in the rigid wall CFD model compared to the FSI model.

中文翻译：

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患者特异性左冠状动脉血流双向流固耦合研究

背景：人体动脉中的血流由于与人类健康息息相关，因此一直备受关注。血流动力学研究揭示了血流的一个重要方面，最终证明这对于做出正确的决定来治疗患有心脏病的患者至关重要。目的：本研究旨在阐明血流的双向流固耦合（FSI）分析以及狭窄对血流动力学参数的影响。方法：基于计算机断层扫描 (CT) 图像构建患者特定的左冠状动脉 3D 模型。假设血液是不可压缩的、均质的，并且表现为非牛顿，而动脉被认为是非线性弹性、各向异性和不可压缩的材料。在边界处应用脉动流动条件。在流体域和固体域之间使用双向耦合 FSI 建模方法。在流体域和固体域变形分析了压力、速度流线和壁面剪应力等血流动力学参数。结果：模拟结果表明，在狭窄附近和狭窄后的再循环区存在压降。注意到狭窄导致高壁应力。结果还表明，与 FSI 模型相比，刚性壁 CFD 模型中的壁剪应力和速度被高估了。模拟结果表明，在狭窄附近和狭窄后的再循环区域存在压降。注意到狭窄导致高壁应力。结果还表明，与 FSI 模型相比，刚性壁 CFD 模型中的壁剪应力和速度被高估了。模拟结果表明，在狭窄附近和狭窄后的再循环区域存在压降。注意到狭窄导致高壁应力。结果还表明，与 FSI 模型相比，刚性壁 CFD 模型中的壁剪应力和速度被高估了。