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Distinguishable Targeting of Non-Small Cell Lung Cancer Using Hyaluronan Functionalized Platinum Nanoclusters and Their Inhibition Behaviors of Proliferation, Invasion, Migration
ChemistryOpen ( IF 2.3 ) Pub Date : 2021-08-06 , DOI: 10.1002/open.202100070
Ting Liu 1 , Xin Huang 2 , Lingyun Zhao 1 , Zhongqing Xiao 1 , Zengbei Li 2 , Yi Xin 3 , Shanshan Yang 1 , Di Guo 1 , Wenfei Zhao 1 , Yang Mi 4 , Hongyun Li 1
Affiliation  

Lung cancer is the leading cause of cancer deaths worldwide and most cancer patients receiving conventional chemotherapy suffer from severe side effects due to the non-selective effects of chemotherapeutic drugs on normal cells. Targeted nanomaterials can obtain excellent accumulation at the tumor site through their active or passive targeting mechanisms, thereby reducing the toxicity of the drugs in various ways. In this study, hyaluronic acid (HA) which could specifically bind to CD44 on the surface of tumor cells, was used to modify amine-caged platinum nanoclusters (Pt NCs-NH2) to obtain targeting HA-Pt NCs-NH2. Based on the differential expression of CD44 on the surface of three lung cells (non-small cell lung cancer cell H1299, small cell lung cancer cell H446, and embryonic lung fibroblast HFL1), HA-Pt NCs-NH2 can differentially enter the three cells and achieve their targeting of non-small cell lung cancer cell (NSCLC) cells. Pt NCs significantly inhibited the proliferation, migration and invasion of NSCLC cells and induced their apoptosis in comparison of classical cisplatin and carboplatin, showing a bright future in early diagnosis and treatment of NSCLC.

中文翻译:

透明质酸功能化铂纳米团簇对非小细胞肺癌的可区分靶向及其对增殖、侵袭、迁移的抑制行为

肺癌是全球癌症死亡的主要原因,大多数接受常规化疗的癌症患者由于化疗药物对正常细胞的非选择性作用而遭受严重的副作用。靶向纳米材料可以通过其主动或被动靶向机制在肿瘤部位获得优异的积累,从而以多种方式降低药物的毒性。本研究采用能特异性结合肿瘤细胞表面CD44的透明质酸(HA)修饰胺笼铂纳米团簇(Pt NCs-NH 2),获得靶向HA-Pt NCs-NH 2 。. 基于三种肺细胞(非小细胞肺癌细胞H1299、小细胞肺癌细胞H446和胚胎肺成纤维细胞HFL1)表面CD44的差异表达,HA-Pt NCs-NH 2可以差异进入这三种细胞。细胞并实现其靶向非小细胞肺癌细胞(NSCLC)细胞。与经典的顺铂和卡铂相比,Pt NCs显着抑制NSCLC细胞的增殖、迁移和侵袭并诱导其凋亡,在NSCLC的早期诊断和治疗中显示出广阔的前景。
更新日期:2021-09-01
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