Mutations that increase sodium currents in excitatory neurons typically produce hyperexcitability and epileptic seizures. Paradoxically, mutations that reduce Na_V1.2 sodium currents also have a similar effect. Two research groups (Spratt et al. and Zhang et al.) have now found that in some excitatory neurons, loss of Na_V1.2 increases intrinsic excitability by altering activation and/or expression of potassium channels.

中文翻译：

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NaVy 悖论：减少钠电流会增加兴奋性

增加兴奋性神经元中钠电流的突变通常会导致过度兴奋和癫痫发作。_{矛盾的是，减少 Na V} 1.2 钠电流的突变也具有类似的效果。两个研究小组（Spratt等人和 Zhang等人）现在发现，在一些兴奋性神经元中，Na _V 1.2 的损失通过改变钾通道的激活和/或表达来增加内在兴奋性。