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Facile synthesis of gold-nanoparticles by different capping agents and their anticancer performance against liver cancer cells
Colloid and Interface Science Communications ( IF 4.5 ) Pub Date : 2021-08-07 , DOI: 10.1016/j.colcom.2021.100482
Mai M. Khalaf 1, 2 , Hany M. Abd El-Lateef 1, 2 , Ibrahim M.A. Mohamed 2 , Magdi E.A. Zaki 3 , Arafat Toghan 3, 4
Affiliation  

Herein, gold -nanoparticles (Au-NPs) were chemically synthesized by the use of carboxymethyl cellulose (CMC) and one of the two capping agents: sodium citrate (SC) or polyethylene glycol (PEG). The prepared Au-NPs by SC (Au/CMC-SC) and PEG (Au/CMC-PG) were compared in morphology, crystallinity, chemistry via FESEM, SAED, FT-IR, XRD, UV–visible spectroscopy, and DLS. The different characterization tools prove the presence of the same chemistry as Au/CMC-NPs and change in the morphology and crystallinity. The morphology of Au/CMC-SC was found as particles in nano-size with a regular and spherical shape. Conversely, the morphology of Au/CMC-PG has irregular shapes. The same functional groups were found in both Au/CMC-SC and Au/CMC-PG which indicate the presence of the same chemical content in the prepared samples. Anticancer action of both prepared gold nanoparticles against liver hepatocellular cells (HepG2) has been investigated. The introduced AuNPs exhibited more significant anticancer action against HepG2 cells at 100 μg concentration of AuNPs. The inhibitory activity of Au/CMC-SC on Hep-G2 cancer cells is superior to that of Au/CMC-PG. The super anticancer activity of Au/CMC-SC is indicated by the extent of the convergence between the cell viability % values of Au/CMC-SC (18%) and the standard drug (9%) used for liver cancer at a dose of 100 μg. The present work provides a simple synthesis approach that will open up a novel probability of functionalized AuNPs for studies in biomedical applications (treatment of HepG2 cells).



中文翻译:

不同封端剂合成金纳米颗粒及其对肝癌细胞的抗癌性能

在此,金纳米颗粒 (Au-NPs) 是通过使用羧甲基纤维素 (CMC) 和两种封端剂之一:柠檬酸钠 (SC) 或聚乙二醇 (PEG) 化学合成的。通过 FESEM、SAED、FT-IR、XRD、紫外-可见光谱和 DLS,比较了 SC (Au/CMC-SC) 和 PEG (Au/CMC-PG) 制备的 Au-NPs 的形态、结晶度、化学性质。不同的表征工具证明存在与 Au/CMC-NP 相同的化学性质以及形态和结晶度的变化。Au/CMC-SC 的形态被发现为具有规则和球形形状的纳米级颗粒。相反,Au/CMC-PG 的形态具有不规则的形状。在 Au/CMC-SC 和 Au/CMC-PG 中都发现了相同的官能团,这表明制备的样品中存在相同的化学成分。已经研究了两种制备的金纳米颗粒对肝肝细胞 (HepG2) 的抗癌作用。引入的AuNPs在100μg浓度的AuNPs下对HepG2细胞表现出更显着的抗癌作用。Au/CMC-SC对Hep-G2癌细胞的抑制活性优于Au/CMC-PG。Au/CMC-SC 的超强抗癌活性通过 Au/CMC-SC (18%) 和用于肝癌的标准药物 (9%) 的细胞活力百分比值之间的收敛程度来表示,剂量为100 微克。目前的工作提供了一种简单的合成方法,将为生物医学应用研究(HepG2 细胞的治疗)开辟功能化 AuNP 的新可能性。引入的AuNPs在100μg浓度的AuNPs下对HepG2细胞表现出更显着的抗癌作用。Au/CMC-SC对Hep-G2癌细胞的抑制活性优于Au/CMC-PG。Au/CMC-SC 的超强抗癌活性通过 Au/CMC-SC (18%) 和用于肝癌的标准药物 (9%) 的细胞活力百分比值之间的收敛程度来表示,剂量为100 微克。目前的工作提供了一种简单的合成方法,将为生物医学应用研究(HepG2 细胞的治疗)开辟功能化 AuNP 的新可能性。引入的AuNPs在100μg浓度的AuNPs下对HepG2细胞表现出更显着的抗癌作用。Au/CMC-SC对Hep-G2癌细胞的抑制活性优于Au/CMC-PG。Au/CMC-SC 的超强抗癌活性通过 Au/CMC-SC (18%) 和用于肝癌的标准药物 (9%) 的细胞活力百分比值之间的收敛程度来表示,剂量为100 微克。目前的工作提供了一种简单的合成方法,将为生物医学应用研究(HepG2 细胞的治疗)开辟功能化 AuNP 的新可能性。Au/CMC-SC 的超强抗癌活性通过 Au/CMC-SC (18%) 和用于肝癌的标准药物 (9%) 的细胞活力百分比值之间的收敛程度来表示,剂量为100 微克。目前的工作提供了一种简单的合成方法,将为生物医学应用研究(HepG2 细胞的治疗)开辟功能化 AuNP 的新可能性。Au/CMC-SC 的超强抗癌活性通过 Au/CMC-SC (18%) 和用于肝癌的标准药物 (9%) 的细胞活力百分比值之间的收敛程度来表示,剂量为100 微克。目前的工作提供了一种简单的合成方法,将为生物医学应用研究(HepG2 细胞的治疗)开辟功能化 AuNP 的新可能性。

更新日期:2021-08-07
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