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Exertional intolerance and dyspnea with preserved lung function: an emerging long COVID phenotype?
Respiratory Research ( IF 5.8 ) Pub Date : 2021-08-06 , DOI: 10.1186/s12931-021-01814-9
Grace Y Lam 1, 2 , A Dean Befus 1, 2 , Ronald W Damant 1, 2 , Giovanni Ferrara 1, 2 , Desi P Fuhr 1 , Michael K Stickland 1, 2 , Rhea A Varughese 1, 2 , Eric Y Wong 1, 2 , Maeve P Smith 1, 2
Affiliation  

The COVID-19 pandemic has resulted in significant acute morbidity and mortality worldwide. There is now a growing recognition of the longer-term sequelae of this infection, termed “long COVID”. However, little is known about this condition. Here, we describe a distinct phenotype seen in a subset of patients with long COVID who have reduced exercise tolerance as measured by the 6 min walk test. They are associated with significant exertional dyspnea, reduced health-related quality of life and poor functional status. However, surprisingly, they do not appear to have any major pulmonary function abnormalities or increased burden of neurologic, musculoskeletal or fatigue symptoms.

中文翻译:

肺功能保留的劳力不耐受和呼吸困难:一种新出现的长期新冠肺炎表型?

COVID-19 大流行已导致全球范围内严重的发病率和死亡率。现在人们越来越认识到这种感染的长期后遗症,称为“长期新冠病毒”。然而,人们对这种情况知之甚少。在这里,我们描述了在长期感染新冠病毒的一组患者中观察到的独特表型,这些患者通过 6 分钟步行测试测得运动耐量降低。它们与严重的劳力性呼吸困难、健康相关的生活质量下降和功能状态不佳有关。然而,令人惊讶的是,他们似乎没有任何重大的肺功能异常或神经系统、肌肉骨骼或疲劳症状负担增加。
更新日期:2021-08-07
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