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Anti-hyperglycemic effect of bran extracts of two traditional rice varieties on alloxan-induced diabetic rats
Indian Journal of Traditional Knowledge ( IF 0.8 ) Pub Date : 2021-08-06
Abubakar Sadiq Tanko, Nazrim Marikkar

Beras merah (BM) and Beras hitam (BH) are two traditional rice varieties popular among the tribal communities living in Ba’kelalan region of Sarawak, East Malaysia. They are grown in fertile paddy lands at 3000 feet above the sea level according to the traditional farming system. In this study, we attempted to investigate the impact of oral administration of bran extracts (RBE) of B. merah and B. hitam on Alloxan-induced diabetic rats. Four-week long treatment of animals with RBE of varying doses (400 and 200 mg/kg) were monitored using anti-hyperglycemic activity and several blood parameters. Changes in body weight and blood parameters, which include blood glucose, liver enzymes and blood proteins, were also assessed using relevant assays. Results showed that RBEs of both B. merah and B. hitam possessed good antidiabetic potentials. The group administered with 400 mg/kg of B. merah (BM 400) showed the highest antidiabetic efficacy compared to 200 mg/kg of the same extract (BM 200). However, RBE of B. hitam displayed anti-hyperglycemic activity only at moderate level. It can be concluded that traditional rice variety B. merah would be a good potent sources of natural anti-diabetic agents.

中文翻译:

两种传统水稻品种麸皮提取物对四氧嘧啶致糖尿病大鼠的降血糖作用

Beras merah (BM) 和 Beras hitam (BH) 是两种传统水稻品种,深受居住在东马来西亚沙捞越 Ba'kelalan 地区的部落社区的欢迎。根据传统的耕作制度,它们生长在海拔 3000 英尺的肥沃稻田中。在这项研究中,我们试图研究口服 B.merah 和 B.hitam 的麸皮提取物 (RBE) 对四氧嘧啶诱导的糖尿病大鼠的影响。使用抗高血糖活性和几个血液参数监测用不同剂量(400 和 200 mg/kg)的 RBE 对动物进行的为期 4 周的治疗。体重和血液参数的变化,包括血糖、肝酶和血液蛋白,也使用相关分析进行了评估。结果表明 B. merah 和 B. hitam 的 RBEs 都具有良好的抗糖尿病潜力。与 200 mg/kg 相同提取物(BM 200)相比,给予 400 mg/kg 美拉果(BM 400)的组显示出最高的抗糖尿病功效。然而,B.hitam 的 RBE 仅在中等水平显示出抗高血糖活性。可以得出结论,传统水稻品种 B. merah 将是天然抗糖尿病药物的良好有效来源。
更新日期:2021-08-07
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