Mental diseases are rising globally. Depression is one among the most common mental disorders with an alarmingly high incidence in India. Mental health care in general is suboptimal in India on account of inadequate resources and lack of awareness. Pluralistic health care delivery model of India including its traditional health care services is less explored in case of mental health for its possibility of adding value to the net mental health care delivery. The objective of the study was to explore the efficacy of an ayurvedic formulation Lasunadya Ghrita (LG) in a multimodal application form in cases of depression and to compare its efficacy with conventional care composed of Escitalopram, Etizolam and Zolpidem (EEZ) provided in an allopathic psychiatric health care setting. Total 52 patients of depression allocated non randomly to Ayurveda LG group and to Allopathy EEZ group were followed up for 4 weeks and evaluated on the basis of HAM-D and SF-36 mean score changes of the participants on a pre and post basis and also for their intergroup comparisons. Statistically significant changes in mean HAM-D and SF-36 Score were observed in a pre-post comparison in both the groups. An intergroup comparison was non- significant for majority of HAM-D domains, barring a few showing the comparable effects of two treatment approaches. Ayurvedic treatment was effective in work and energy domain and gastrointestinal symptoms. Pre and post mean changes in HAM-D and SF-36 Score in two groups have shown significant changes in both the groups suggestive of their individual efficacy. Insignificant difference in most domain scores of HAM-D and SF-36 in an inter group comparison was suggestive of comparable efficacy of LG multi route application with EEZ allopathy care.

中文翻译：

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Lasunadya Ghrita（一种阿育吠陀制剂）的多途径（口服和鼻腔）应用对原发性抑郁症的影响：来自非随机开放标签临床试验的推论

精神疾病在全球范围内呈上升趋势。抑郁症是最常见的精神障碍之一，在印度的发病率高得惊人。由于资源不足和缺乏意识，印度的精神卫生保健总体上并不理想。印度的多元化医疗保健提供模式，包括其传统的医疗保健服务，在心理健康方面的探索较少，因为它有可能为净心理保健提供增值。该研究的目的是探索阿育吠陀制剂 Lasunadya Ghrita (LG) 在抑郁症情况下的多模式应用形式的功效，并将其功效与由艾司西酞普兰、依替唑仑和唑吡坦 (EEZ) 组成的传统疗法在对抗疗法中提供的疗效进行比较。精神卫生保健环境。总共 52 名非随机分配到 Ayurveda LG 组和 Allopathy EEZ 组的抑郁症患者进行了为期 4 周的随访，并根据参与者的 HAM-D 和 SF-36 平均评分变化进行了评估，并在前后基础上进行了评估用于他们的组间比较。在两组的前后比较中观察到平均 HAM-D 和 SF-36 分数的统计学显着变化。大多数 HAM-D 域的组间比较不显着，除非少数显示两种治疗方法的可比效果。阿育吠陀疗法对工作和能量领域以及胃肠道症状有效。两组中 HAM-D 和 SF-36 分数的前后平均变化均显示出两组的显着变化，表明它们的个体功效。