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COVID-19, Ebola virus disease, and Nipah virus infection reclassification as novel acute immune dysrhythmia syndrome (n-AIDS): potential crucial role for immunomodulators
Immunologic Research ( IF 4.4 ) Pub Date : 2021-08-06 , DOI: 10.1007/s12026-021-09219-y
Mina T Kelleni 1
Affiliation  

In this manuscript, COVID-19, Ebola virus disease, Nipah virus infection, SARS, and MERS are suggested to be considered for a novel immunological reclassification as acute onset immune dysrhythmia syndrome (n-AIDS) due to altered monocytic, Th1/Th2, as well as cytokines and chemokines balances. n-AIDs is postulated to be the cause of the acute respiratory distress and multi-inflammatory syndromes which are described with fatal COVID-19, and immunomodulators are suggested to effectively manage the mentioned diseases as well as for other disorders caused by Th1/Th2 imbalance. Meanwhile, para COVID syndrome is suggested to describe various immune-related complications, whether before or after recovery, and to embrace a potential of a latent infection, that might be discovered later, as occurred with Ebola virus disease. Finally, our hypothesis has evolved out of our real-life practice that uses immunomodulatory drugs to manage COVID-19 safely and effectively.



中文翻译:

COVID-19、埃博拉病毒病和尼帕病毒感染重新分类为新型急性免疫节律失常综合征 (n-AIDS):免疫调节剂的潜在关键作用

在这份手稿中,建议考虑将 COVID-19、埃博拉病毒病、尼帕病毒感染、SARS 和 MERS 进行新的免疫学重新分类为急性发作性免疫节律失常综合征 (n-AIDS),原因是单核细胞、Th1/Th2、以及细胞因子和趋化因子的平衡。n-AID 被认为是致命的 COVID-19 描述的急性呼吸窘迫和多发性炎症综合征的原因,建议使用免疫调节剂来有效控制上述疾病以及由 Th1/Th2 失衡引起的其他疾病. 同时,建议用 para COVID 综合征来描述各种与免疫相关的并发症,无论是在康复之前还是之后,并包含潜在的感染,这种感染可能会在以后发现,就像埃博拉病毒病一样。最后,

更新日期:2021-08-10
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