Amyloid-beta (Aβ) aggregation, the pathological process believed to be a key triggering event for Alzheimer's, is studied using atomic-scale probes of peptide dynamics. All the probes point to a segment in the C-terminal region of Aβ acting as a hotspot in the initiation of Aβ aggregation, particularly in the more toxic Aβ42 variant.

中文翻译：

---

淀粉样蛋白-β 肽错误折叠途径的早期分歧

淀粉样蛋白-β (Aβ) 聚集，被认为是阿尔茨海默氏症的关键触发事件的病理过程，使用肽动力学的原子级探针进行研究。所有探针都指向 Aβ C 端区域中的一个片段，作为 Aβ 聚集起始的热点，尤其是在毒性更大的 Aβ42 变体中。